e-Cigarettes: lessons for Inhalation technologists

e-Cigarettes: lessons for Inhalation technologists

July 10, 2016

e-Cigarettes: lessons for Inhalation technologists Electronic cigarettes (ECs), or e-cigarettes, produce aerosols through heating and vaporizing solutions. They are marketed for recreational use and are not much regulated. They share a common purpose as inhalation products: they produce aerosols intended to be orally inhaled. ECs are much cheaper and more popular than pharmaceutical inhalers. Their efficiency at delivering nicotine satisfies their users, yet, their delivery mechanism is a mystery. A selection of vaping devices available in Hong Kong were tested in vitro with commercial e-liquids and laboratory formulations based on glycerin. Their aerosolisation profiles were studied by laser scattering and were compared to tobacco industry claims. Conclusion: nicotine is more likely to be delivered via the buccal cavity than the lung. The array of flavourings and formulation excipients used is as broad as it is exotic (bubble gum, butterscotch, gourmet cinnamon, pie crust, root beer, propylene glycol and glycerin), it is an unheard of open-access worldwide clinical trial of excipients: exploring and monitoring it is a must.

Seminar given at the Chiesi 3i meeting, Newport Wales UK, 7 July 2016.

Full slides are available via the Aedestra Ltd website (www.aedestra.com) or on slideshares: http://www.slideshare.net/progueda/ecigarettes-lessons-for-inhalation-technologists, and on request: info@aedestra.com.

Aedestra Ltd is a product development company in the field of inhaled drug product. We make developing inhaled products easy, so you can focus on delivery. We drive initiatives; you realise opportunities. We can help you develop the right product in the right way by providing strategic and technical expertise: reducing cost, time and risk. Get in touch now to expand and develop your inhaled portfolio.

Philippe Rogueda (1), Philip Chi Lip Kwok (2), Lu Hou (2)
(1) Aedestra Limited, 11/F, Rykadan Capital Tower, 135-137 Hoi Bun Road, Kwun Tong, Kowloon, Hong Kong SAR.
(2) Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR.